Self-reported non-adherence to immunosuppressive medication detected by the BAASIS predicts allograft rejections in kidney transplant recipients
In 226 kidney transplant recipients followed for up to four years, a positive result on the brief self-report BAASIS adherence tool was associated with nearly threefold higher risk of biopsy-proven rejection, supporting its use in routine post-transplant care.
Study design
Prospective cohort of 226 consecutive kidney transplant recipients (Medical University of Vienna, 2018-2019). The validated BAASIS self-report tool was administered at the first outpatient visit and at months 3, 6, 9, 12, and 24, with biopsy-proven allograft rejection over up to 4 years as the primary endpoint.
Key findings
Over a median 3.7-year follow-up, 55% of recipients reported non-adherence at least once. Non-adherent recipients experienced more rejections than adherent ones (24% vs 7%; P<.001), and in a time-dependent Cox model, prior non-adherence carried an adjusted hazard ratio of 2.90 (95% CI 1.51-5.58) for rejection.
Clinical implications
Incorporating the brief BAASIS into routine post-transplant follow-up may flag clinically meaningful medication non-adherence early and enable timely intervention to protect the allograft.
Category
Transplant
Source
Nephrology Dialysis Transplantation
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