ISCN 2024 - An International System for Human Cytogenomic Nomenclature (2024).
The 2024 edition of the International System for Human Cytogenomic Nomenclature (ISCN) represents one of the most significant revisions in the standard's history, introducing standardized nomenclature for genomic mapping for the first time.
Background
The ISCN is the standardized international nomenclature established by the International Standing Committee on Human Cytogenomic Nomenclature for describing chromosomal and genomic abnormalities detected by techniques including karyotyping, fluorescence in situ hybridization, microarray, genome mapping, region-specific assays, and high-throughput sequencing. With a history spanning over six decades, the standard was revised by the committee in 2024 and officially published in September 2024.
Key recommendations
The ISCN 2024 edition incorporated feedback from the cytogenomics community to provide a more user-friendly and organized presentation of general rules, improved example descriptions, more representative examples, and additional abbreviations. Nomenclature for describing the findings of genomic mapping has been included for the first time, and the committee provided standardized nomenclature to ensure consistency irrespective of the cytogenomic technology used.
Clinical implications
The report highlighting the main changes serves as a guide to assist laboratories in the transition to implementing ISCN 2024 as the current nomenclature for describing cytogenomic findings. Standardized, technology-agnostic reporting supports clear and consistent communication of cytogenetic and molecular results in both clinical and research settings.
Category
International
Source
Cytogenet Genome Res
More from ASNRT News
Browse the latest news, society announcements, KDIGO guideline updates, and AJNT issue releases on the ASNRT newsroom.