Continuous Kidney Replacement Therapy and Survival in Children and Young Adults: Findings From the Multinational WE-ROCK Collaborative
An international study of 980 critically ill children and young adults on continuous kidney replacement therapy found about two-thirds survived to ICU discharge, and survival was not linked to CKRT dose, filter type, or anticoagulation method.
Background
The epidemiology and outcomes of continuous kidney replacement therapy (CKRT) in children and young adults are poorly characterized despite its use for acute kidney injury and volume overload in critical illness.
Key findings
In 980 patients from birth to 25 years treated 2015-2021 (median age 8.8 years), CKRT began a median of 2 days after ICU admission and lasted a median of 6 days; continuous venovenous hemodiafiltration was the most common modality and citrate anticoagulation was used in 62%. 64.1% survived to ICU discharge, with CKRT dose, filter type, and anticoagulation similar between survivors and non-survivors.
Clinical implications
Survival in pediatric CKRT appears driven more by underlying illness and comorbidity than by circuit-prescription details, providing benchmark data to inform practice and future trials in this understudied population.
Category
News
Source
American Journal of Kidney Diseases
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