Uremic Pruritus Pathogenesis, Revisited

Authors

EAS Attia, AA Hassan

Citation

Arab J Nephrol Transplant. 2014;7(2):91–96.

Full text (excerpt)

Uremic Pruritus Pathogenesis, Revisited Enas A.S. Attia¹, Ahmed A. Hassan² Department of Dermatology, Venereology and Andrology, Ain Shams University Hospital, Cairo, Egypt. Department of Nephrology, Internal Medicine, Zagazig University Hospital, Zagazig, Egypt Abstract Introduction: Uremia is the most important systemic cause of pruritus. Uremic pruritus (UP) was found to affect 50-90% of patients undergoing dialysis and about 25% of patients with chronic kidney disease (CKD). Despite its high prevalence, morbidity and the marked influence on quality of life, UP remains poorly characterized. Review: Triggering factors for UP may include cutaneoxerosis, uremic toxins, systemic inflammation and associated common co-morbidities such as diabetes mellitus, endocrinopathies,viral hepatitis and uremic neuropathy. Moreover, high pre-dialysis levels of blood urea nitrogen (BUN), β2-microglobulin, calcium and phosphate, as well as parathyroid hormone (PTH) were found to be related to UP. A new hypothesis of glycation, with advanced glycation end products (AGEs) accumulation in stratum corneum has been proposedas a possible underlying cause of UP. Common treatments used for UP include antih

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The Arab Journal of Nephrology and Transplantation is the peer-reviewed open-access journal of ASNRT, published since 2008.

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