The Diagnostic Value of Detection of CD20 Positive Infiltrates in Renal Biopsies with Acute Allograft Rejection: A pilot study

Authors

A Genina, W Ismail, AR Soliman

Citation

Arab J Nephrol Transplant. 2014;7(2):97–101.

Full text (excerpt)

The Diagnostic Value of Detection of CD20 Positive Infiltrates in Renal Biopsies with Acute Allograft Rejection: A pilot study Ashraf Gemina¹, Wesam Ismail², Amin Roshdy Soliman³ Internal Medicine Department, BeniSuef University, Cairo, Egypt Pathology Department, BeniSuef University, Cairo, Egypt Internal Medicine Department, Cairo University, Cairo, Egypt Abstract Introduction: The recognition of antibody mediated rejection has led to re-appreciation of the role of B cells in acute and chronic allograft rejection. The presence of CD20 positive lymphocytic infiltrates in acute cellular rejection was associated with poor clinical outcomes and reduced graft survival. Recently molecular gene analysis has shown that grafts with antibody mediated rejection (ABMR) have a wide expression of CD20. Methods: We reviewed 28 renal allograft biopsies, including 13 biopsies from patients who experienced acute ABMR and a matched group of 15 patients with acute T cell mediated rejection (TCMR), to serve as controls. All biopsies were stained by anti-CD20 and anti-CD8 antibodies. Results: All twenty-eight biopsies were found to have CD20 positive cells within their interstitial infiltrate. The dis

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The Arab Journal of Nephrology and Transplantation is the peer-reviewed open-access journal of ASNRT, published since 2008.

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