Tacrolimus Target Trough Level (Post-Transplant)
Find the recommended tacrolimus trough target for a kidney transplant recipient based on time since transplant and immunologic risk, to support therapeutic drug monitoring and dose adjustment.
When to use it
Use during post-transplant follow-up to set or check tacrolimus trough targets against the recipient's phase and immunologic risk.
Category
Transplantation
References
- KDIGO Clinical Practice Guideline for the Care of Kidney Transplant Recipients. Am J Transplant. 2009;9(Suppl 3):S1-S155. https://kdigo.org/guidelines/transplant-recipient/
- Ekberg H et al. Reduced exposure to calcineurin inhibitors in renal transplantation. N Engl J Med. 2007;357:2562-75. PMID: 18094377
Common clinical questions
- What tacrolimus trough should I target in the first months after transplant?
- Early after transplant, higher troughs of roughly 6 to 10 ng per mL are typical, tailored to immunologic risk, then tapered toward 4 to 7 ng per mL for maintenance. Lower the target when BK viremia appears; hold it higher for higher-immunologic-risk recipients. Always interpret the trough alongside the full immunosuppression regimen.
About NephroMind
This calculator is part of NephroMind, a free clinical decision-aid platform from the Arab Society of Nephrology and Renal Transplantation (ASNRT) — over 128 bedside nephrology calculators plus a renal drug-dosing database, coded by a practicing transplant nephrologist.