Glomerulonephritis Recurrence Risk After Kidney Transplant
Estimate how likely a recipient's original glomerulonephritis is to recur in the allograft, so the transplant team can plan surveillance, set expectations, and counsel the recipient before and after transplant.
When to use it
Use during transplant evaluation and early follow-up when the cause of native kidney failure was a glomerulonephritis. Recurrence risk informs monitoring intensity and donor choice, but a high risk is a reason to plan, not to deny transplantation.
Category
Transplantation. Related searches: gn recurrence transplant, fsgs recurrence risk, iga nephropathy recurrence, recurrent glomerulonephritis.
References
Cosio FG, Cattran DC. Recent advances in our understanding of recurrent primary glomerulonephritis after kidney transplantation. Kidney Int. 2017;91(2):304-314
KDIGO Clinical Practice Guideline for the Care of Kidney Transplant Recipients. Am J Transplant. 2009;9(Suppl 3):S1-S157
Common clinical questions
How likely is my patient's glomerulonephritis to come back after a kidney transplant? It depends on the original disease. Primary FSGS recurs in about 30 percent, higher with prior recurrence, rapid native progression, and younger age. IgA nephropathy recurs histologically in up to half of grafts but causes graft loss less often. Membranous nephropathy recurs in roughly 40 percent and anti-PLA2R titres predict it. C3 glomerulopathy and dense-deposit disease recur very frequently.
About NephroMind
This calculator is part of NephroMind, a free clinical decision-aid platform from the Arab Society of Nephrology and Renal Transplantation (ASNRT) — over 125 bedside nephrology calculators plus a renal drug-dosing database, coded by a practicing transplant nephrologist.